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Therapy of AHA depends on the severity and causative mechanism

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Further, studies on a comprehensive understanding of the mechanisms or pathways that regulate the reversible nature of the corresponding modifications should be undertaken

Preclinical studies have shown that co-targeting ferroptosis and pyroptosis (e.g., GPX4 inhibitor + GSDMD activator) can overcome compensatory resistance by engaging complementary cell death mechanisms, amplifying DAMP release, and enhancing T cell infiltration (60, 181)

6, 2005, pp

The mechanism by which NAC decreased ROS or the identity of ROS was not specified