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Research shows that quercetin can reduce arthritis in animal models and decrease pain sensitivity by blocking nociceptive effects

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Studies have shown that high doses of antioxidants such as vitamin C, vitamin E or N-acetylcysteine can suppress adaptive cellular responses, impair exercise-induced mitochondrial biogenesis and even promote tumour growth in certain models by interfering with ROS-dependent signalling processes, apoptosis processes or immune activation [161,162]

Moise KJ Jr, Ling LE, Oepkes D, Tiblad E, Verweij E, Lopriore E, et al

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Likewise, most vascular studies use surgical ovariectomy rather than chemotoxic models