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In contrast, cysteine (Cys) and threonine (Thr) deprivation led to cell death via distinct pathways: ferroptosis for Cys starvation, whereas Thr deprivation triggered a previously uncharacterized form of cell death, which could be entirely suppressed by methionine (Met) co-starvation, and mTOR or translational inhibition

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21 , 46 Additionally, the PDI can impact how lipid-based nanoparticles behave in the body, affecting their circulation time, absorption, and distribution