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It was used in a once-daily multiple ascending dose phase Ib clinical trial and a 41-day phase IIa trial in overweight and type 2 diabetic patients, and the general safety and tolerability of MEDI0382 were established, as was its placebo-corrected efficacy in reducing fasting blood glucose (1.7 mmol/L), postprandial glucose excursions following a mixed meal test (22.6% area under the curve 04 hours), body weight (2.1 kg), and liver fat (19.6%)

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Pharm Biol 61(1):3749 Wu L, Dong B, Chen Q, Wang Y, Han D, Zhu X, Liu H et al (2023) Effects of curcumin on oxidative stress and ferroptosis in acute ammonia stress-induced liver injury in gibel carp (Carassius gibelio)

Furthermore, we found that Sec24C overexpression elevated the expression of SLC7A11 at PM level, but the effect was abrogated upon exposure to Brefeldin A (Fig