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It may take repeated or prolonged exposure to items containing nickel to develop a nickel allergy

Lei L, Xu X, Gong C, Lin B, Li F
doi: 10.1016/j.jplph.2010.07.01

Underlying infections can be a trigger to upregulating your immune response

Parazzini F

By contrast, the Cterminal cysteine of the CXXC motif of PDI is positioned perfectly to resolve the mixed disulphide
