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The ferroptosis inducers such as glutamate, erastin are able to drain GSH and inactivate the enzymatic activity of GPX4 via blocking the import of cystine by the cystine/glutamate antiporter (system X c ) [27, 28] (Fig

Wan et al

Bacterial translocation in acute liver injury induced by D- galactosamine

In mouse hepatocytes, IL-6-mediated activation of the JAK/PI3K/Akt signaling pathway has been shown to inhibit hepatocyte apoptosis [145]

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