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2.Measured by its ability to enhance the outgrowth of SH-SY5Y cells

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The advent of targeted therapies directed against key cytokines involved in the different cell death pathways highlights the clinical importance of identifying the leading pathways to guide treatment choices: Patients whose phenotype is driven by TNF-alpha-induced necroptotic cell death may benefit from TNFi, and interleukin-1 inhibitors have markedly improved the outcome of patients with autoinflammatory diseases driven by increased pyroptosis [23, 25]

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Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1

193,194 Data from TCGA suggest that RET expression is significantly downregulated in HCC tissues compared to adjacent tissues