oxygen dependent intracellular killing ros production glutathione Identification of cytotoxic, glutathione-reactive moieties inducing accumulation of reactive species via depletion Generation of reactive oxygen species

(visit source) Mohebi-Nejad A, Bikdeli B

During the experiment, larvae were maintained in a controlled environment at 21 C under a 12:12 h light-dark photoperiod and were provided with a cube of fresh diet daily to minimize losses of ITCs to evaporation

In vitro experiments confirmed that A 25-35 treatment significantly inhibited the activation of the NRF2/SLC7A11/GPX4 signaling pathway in HT22 cells, upregulated the expression of Fe 2+ , TFR1, ACSL4, MDA, and GSSG, and decreased the expression of FTH1, SOD, and GSH, as well as the GSH/GSSG ratio, resulting in dysregulated neuronal iron metabolism, impaired amino acid antioxidant systems, mitochondrial dysfunction, and ferroptosis, which ultimately promoted neuronal injury

R.ValkaiS.BrsA

The first proportion of the mobile phase was maintained at 30% for 02 min, increased linearly from 30 to 100% for 225 min, and then maintained at 30% for 2535 min

J Exp Med (2002) 195:5970.10.1084/jem.20010659 45 KaminskiMMRothDKrammerPHGulowK