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First, all the rats were anesthetized via an intraperitoneal injection of 2% pentobarbital sodium (75 mg/kg), and the hair of the right posterior leg was removed

190,191 Due to the close connection between the gut and lung microbiomes, we also propose a strong association between adaptive immunity and the lung microbiome from the perspective of adaptive immunity-associated cells

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Mechanistically, NNMT suppression increased adipose SAM and NAD, upregulated polyamine flux enzymes (ODC, SSAT), and altered histone methylation consistent with a shift toward oxidative metabolism [2]