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In summary, dysregulated histone deacetylation establishes an epigenetic environment conducive to AML progression and therapeutic resistance

Creff J, Malaquin L, Besson A

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Inhibition of recruitment of RNA polymerase II Metformin Metformin, originally developed as an oral medication, is widely used to treat type 2 diabetes, to lower blood glucose levels by improving insulin sensitivity, to reduce hepatic glucose output, and to enhance muscle glucose uptake

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After intravenous injection of iNSC-EVs, 5xFAD mice show improved cognitive function, reduced A deposition, and diminished neuroinflammation (Gao et al., 2023)