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The guidance around the management of B12 deficiency in people treated with metformin is a little unclear, owing to a lack of clinical evidence in this area

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J Human Hypert 28:230235 Eleutrio RMN, Nascimento FO, Arajo TG, Castro MF, Filho TPA, Filho PAM, Eleutrio J, Elias DBD, Lemes RPG (2019) Double-blind clinical trial of arginine supplementation in the treatment of adult patients with sickle cell anaemia

This is an area where the mechanism is well-characterized, the animal data is robust, and the safety profile appears favorable, but rigorous human trial data remains limited

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Song TY, Chen CL, Liao JW et al (2010) Ergothioneine protects against neuronal injury induced by cisplatin both in vitro and in vivo
