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doi: 10.1186/s12951-022-01424-7 98 Jing-JingWMichelle Kwan-YeeSYu-XinJThomas Ho-YinLDavid WaiCHuo-GangWet al

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Molecular mechanisms of superoxide production by the mitochondrial respiratory chain

In schizophrenia (SZ), Down Syndrome, and bipolar disorder (BD), increased brain insulin resistance and reduced IGF-1 signaling drive allostatic load/overload, leading to physiological dysregulation and the presentation of more severe symptoms throughout the body [44,45,46]
