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DOI: 10.2174/1570159X13666160502153 022
Signal Transduct Target Ther 7(1):274 Umar S, Palasiewicz K, Volin MV et al (2021) Metabolic regulation of RA macrophages is distinct from RA fibroblasts and blockade of glycolysis alleviates inflammatory phenotype in both cell types
In agreement, ASMase knockout mice exhibited enhanced hepatotoxicity and liver damage after APAP overdose, while hepatocytes challenged with U18666A, which induces the accumulation of cholesterol in lysosomes, sensitized hepatocytes to APAP-mediated cell death
In particular, treatment effect size may differ among each combination and be affected by patient clinical situations and targeting outcomes
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