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Description
This review integrates current evidence on how brain peptides contribute to AD pathophysiology, summarizes recent progress in peptide-based therapeutic strategies and delivery platforms, and critically examines the remaining barriers to clinical translation, including bloodbrain barrier penetration, metabolic stability, off-target effects, and the need for biomarker-guided patient stratification

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Determines expedited reporting timelines Critical for SUSAR identification in clinical trials Supports signal detection Impacts regulatory submissions (e.g., expedited ICSRs) Pro Tip for PV Professionals: Expectedness assessment must always be performed against the current version of the Reference Safety Information (RSI)- not outdated labeling

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