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PUFA-CoAs are subsequently used for the synthesis of phospholipids, including phosphatidylethanolamine, and loss of ACSL4 results in significant resistance to ferroptosis induced by GPX4 deficiency [41]

Additionally, the gut microbiota is essential for the existence and functionality of intestinal CD8+ T cells, as well as their capacity to modulate other immune cell populations, including natural killer cells, plasmacytoid dendritic cells, and marginal zone B cells (9294)

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In addition, p53 can transcriptionally upregulate mitochondrial glutaminase ( GLS2 ) expression in several cancer cells under unstressed and stressed conditions ( e.g

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