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3.2.3.3 Nuclear factor-kappa B activation (NF-B) activation Ataxia telangiectasia mutated (ATM) kinase, an autophos-phorylated protein that is normally found as an inactive dimer in the nucleus and cytoplasm, functions in DSB repair

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Contemporaneously, studies of synthetic guanidine analogues discovered a compound referred to as flumamine and suggested that it might act in patients with malaria by lowering blood glucose, thereby reducing the ability of the malarial parasite to survive