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When the pancreas inflames, massive amounts of the enzyme lipase leak into the bloodstream

This timeline assumes consistent application and the avoidance of triggers (UV exposure without protection, friction, irritating products) that would re-activate melanin production in the same zone

A., Hsu K.-T., Liao C.-Y., Lee Y.-Y., Tseng C.-M., Lee Y.-T., Ni C.-K

The study points toward pancreatic enzyme therapy as a way to reduce unpleasant symptoms like diarrhea and abdominal pain for IBS sufferers who have underlying pancreatic insufficiency