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Recent research demonstrated that the distinct insulinotropic potential of incretins in diabetes is highlighted by a Gs/Gq signaling shift in pancreatic -cells chronically exposed to high glucose 41

(2011) found red blood cell glutathione concentrations 46% lower in elderly subjects with fractional synthesis rates 45% slower than younger controls

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Chernov, V

Although degradation-synthesis coupling would be consistent with Figures 3A,B, it is also unexplained why metabolism of GABA should be so important for glutamate production, since GABA in adult animals contributes so relatively little to the return flux toward astrocytes ( V cyc )
