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Zhao et al., 2016), as discussed in more detail in Section 4 E3 ligases and deubiquitinating enzymes in circadian regulation. 2.3 Turnover of core clock proteins The timed degradation of core clock proteins by the ubiquitin-proteasome system ensures proper cycling between repression and activation within the feedback loop, maintaining clock period length

Cell tracking with 5-ethynyl-2-deoxyuridine (EdU) and confocal live imaging showed that in epithelioids, as in vivo, some cells exit the basal layer, migrate through the suprabasal layers and are eventually shed (Fig

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Notably, high concentrations of zinc are also found in the retina and choroid of the eye 23,24