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But during perimenopause and menopause, several critical pathways slow down: Growth hormone (GH) production declines affecting muscle mass, fat metabolism, skin quality, and recovery Inflammatory markers increase contributing to joint pain, brain fog, and metabolic dysfunction Sleep architecture degrades less deep sleep means less cellular repair, less growth hormone release, and more fatigue Collagen synthesis drops dramatically women lose roughly 30% of their collagen in the first five years of menopause, accelerating skin aging, joint stiffness, and connective tissue weakness Gut lining integrity weakens leading to increased inflammation, food sensitivities, and nutrient malabsorption Sexual function changes declining hormones reduce libido, arousal, and tissue health Peptide therapy doesnt replace what menopause takes away it reactivates the pathways that menopause suppresses

Lobular extrusions of skin, fat and fascia tissue in Stage 3 represent significant loss of elasticity in the adipofascia drastically inhibiting mobility

The key is ensuring sufficient leucine content and total protein intake throughout the day

ROLE OF AsA-GSH CYCLE IN MITIGATING ROS-MEDIATED STRESS ROS is produced during aerobic reactions when oxygen is partially reduced or activated

doi: 10.1038/nrendo.2017.181 26

Rev Brasileira de Nutrio Esportiva