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Phenelzine versus imipramine in the treatment of probable atypical depression: defining syndrome boundaries of selective MAOI responders

Neurobiol Aging 34:1519.e13-1519.e17

doi: 10.1038/s41598-022-23730-8

Preclinical data from the University of Arizona showed maximal receptor occupancy at 10^-9 M concentrations in cortical neuron cultures, with no additional signaling observed when concentrations increased tenfold

Yescarta, a second CD19-specific CAR-T product, was approved on October 18, 2017, for adult patients with relapsed/refractory large B-cell lymphoma (R/R LBCL), including diffuse large B-cell lymphoma (DLBCL), primary mediastinal B-cell lymphoma (PMBCL), high-grade B-cell lymphoma (HGBCL), and transformed follicular lymphoma (TFL), after two or more lines of systemic therapy (39)

Three receptor subtypes exist (AMY1, AMY2, AMY3) based on which RAMP is associated