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Under basal conditions, NRF2 is kept inactive through binding to its negative regulator KEAP1, which is a redox-regulated substrate adaptor for the Cullin (Cul)3-RING-box protein (Rbx)1 ubiquitin ligase complex that directs NRF2 for degradation [10]

Exosomal miR-499a-5p from human umbilical cord mesenchymal stem cells attenuates liver fibrosis via targeting ETS1/GPX4-mediated ferroptosis in hepatic stellate cells

For example, in the Fenton reaction, O 2 is oxidized to O 2 and H 2 O 2 is reduced to hydroxyl radical (HO ), which is the most oxidizing species (E = 2310 mV)

Havaux M, Eymery F, Porfirova S, Rey P, Dormann P (2005) Vitamin E protects against photoinhibition and photooxidative stress in Arabidopsis thaliana

81 XuanJ.ChenS.NingB.TollesonW

In preclinical neurodegeneration models, Tregs provide dual benefits: Suppression of neuroinflammatory cascades and induction of neurotrophic factor release, including CDNF, via crosstalk with neural substrates [248250]