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The strongest human evidence is topical, including the Leyden 2002 photoaging trial and a 2023 IRB-approved 21-woman topical NEEL gel study reporting an average 28% increase in skin collagen density at 3 months

Prebiotics ferment in the colon, which may result in gas, bloating, diarrhea, or stomach pain, especially when used in high doses

doi: 10.1016/j.phrs.2021.105742 79 RathSDasLKokateSBPratheekBMChattopadhyaySGoswamiCet al

Accelerates Pigmentation Repair: Together, they slow melanin production and help fade existing dark patches caused by melasma, acne scars, or sun damage

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Structures of the CCK-8CCK1RG s , SR146131CCK1RG s , CCK-8CCK2RG q , and gastrin-17CCK2RG q complexes were determined with global resolutions of 3.2, 3.0, 3.1, and 3.1 , respectively (Fig