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Although AKRs together with other oxidoreductases can detoxify the RCS to prevent tissue injury, they can trigger ROS signaling [46]

Pan J., Li H., Ma J.F., et al., Curcumin Inhibition of JNKs Prevents Dopaminergic Neuronal Loss in a Mouse Model of Parkinson's Disease Through Suppressing Mitochondria Dysfunction, Translational Neurodegeneration 1 (2012): 16

Furthermore, peripheral inflammatory cytokines can directly damage vascular endothelial cells, while the damaged areas highly express adhesion molecules, promoting leukocyte aggregation and further exacerbating local inflammation [421]

Glutathione injections are generally recognized as safe (GRAS) so there is unlikely to be a significant effect

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