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Adrenoleukodystrophy: phenotype, genetics, pathogenesis and therapy

doi: 10.1016/J.JCMGH.2018.04.003 190 SahooDKBorcherdingDCChandraLJergensAEAtherlyTBourgois-MochelAet al

MyD88-dependent signaling drives toll-like receptor-induced trained immunity in macrophages

This seems to be associated with glial-specific cystine-glutamate transporter, which regulates ambient glutamate concentration and hence the strength of glutamatergic transmission

The cells were initially stimulated with 1 g/mL of LPS for 30 min to induce an inflammatory response, followed by treatment with various concentrations of APE (ranging from 62.5 to 2000 g/mL) for 24 h

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