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Its safety and effectiveness for human use have not been confirmed through comprehensive clinical trials

This could include alterations in sleep duration or sleep architecture

Similarly, the quinolinium containing parent analogue 1-MQ also lacked passive diffusion properties (Table 1), suggesting that the lipophilicity and drug-like permeability properties of analogues within the methylquinolinium series had to be improved via chemical modification

Acta Biochim Pol 2010;57:119123

Yaku, K., Okabe, K., Hikosaka, K., & Nakagawa, T

Vance et al., 2022)