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There are six IGFBPs types (containing approximately 200300 AAs) that regulate IGF signaling and prolong its half-life, and they bind more than 90% of IGF-1 present in circulation (about 1% of IGF-1 in circulation are in a free-active form), simultaneously blocking its binding to IR (42, 43)
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Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. Int J Mol Sci 19(7):1987
