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2020 Feb 1;45(3):201-207

Larazotide acetate (AT-1001) is a tight-junction regulating peptide that strengthens epithelial barrier integrity across mucosal surfaces including the oral epithelium

Peptide interventions utilize brightening compounds inhibiting tyrosinase enzyme controlling melanin production, exfoliation-promoting peptides accelerating hyperpigmented cell turnover, and antioxidants preventing ongoing melanin formation from oxidative stress

Adverse reactions occurred in 4 people (13.8%) in Group A and 1 person (3.3%) in Group B

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