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Although several steps in this proposed general mechanism still need detailed confirmation in ex vivo in vitro and in in vivo models through combined metallomic-metabolomic approaches [211,212] and through a systematic physico-chemical study of the involved molecular systems, the collected information allows us to design experimental approaches aimed at verifying the missing steps of the comprehensive model

Meta-analyses of blood homocysteine levels for gender and genetic association studies of the MTHFR C677T polymorphism in schizophrenia

Genome Biol 15:R89

Vegetarians and vegans seeking to prevent deficiency rather than correct existing insufficiency may maintain levels with consistent oral supplementation

Dietary deficiency may be treated with oral cyanocobalamin 50150 g or 1,000 g daily until corrected

Try to gradually increase your fiber intake and drink plenty of water to avoid bloating