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This comprehensive review discusses the host innate and acquired immune response involved in the pathogenesis of AOM, including information on viral-induced pathological changes in the nasopharynx and the middle ear in animal models

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To avoid relying on statistical differences that do not involve a clear clinical impact, the concept of minimal clinically important differences (MCID) was employed (27) as is commonly used in PD drug trials and observational studies (2830)

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First introduced in the 1950s to identify hydrogen donors in natural substances, the DPPH assay has since been used to quantify the antioxidant potential of phenolic compounds, foods, and biologically relevant samples (Roginsky and Lissi 2005)