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Recommendations To advance therapeutic targeting of NSCLC metabolism and translate laboratory discoveries into clinical benefits, we propose the following recommendations: 1

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TLC-2716 was well tolerated and improved atherogenic lipid parameters in healthy individuals Given the favorable efficacy and toxicological profile in preclinical species, a randomized, placebo-controlled phase 1 clinical trial of TLC-2716 was conducted in humans (ClinicalTrials.govNCT05483998, from 27 July 2022 to 18 June 2023

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