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Genetic and chemical inhibition of IRF5 suppresses pre-existing mouse lupus-like disease

Mohammad, Khan UA, Saifi Z, Bora J, Warsi MH, Abourehab MAS, et al

10.1007/s12192-016-0667-7 (2016)

It is synthesized from glutamate and ammonia by the enzyme glutamine synthetase, and is stored and released predominantly by the skeletal muscle [1]

"The complex evolutionary history of aminoacyl-tRNA synthetases"
