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This variation in pO2, in particular, differentially regulates the compartmentalization and functioning of the transcription factors hypoxia-inducible factor-1 (HIF-1) and nuclear factor-B (NF-B)

Clinical studies have shown that a combination of glycine and N-acetylcysteine reliably increases low glutathione levels and thus reduces oxidative stress

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Like normal stem cells, CSCs can proliferate, engage in self-renewal, and are often implicated in the recurrence of tumors after therapy [1, 2]

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