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The mPTP is a multi-protein complex that, when persistently open, causes mitochondrial swelling, potentially leading to rupture of the mitochondrial outer membrane

Biomed Pharmacother 137:111274 Yao Y, Song Q, Hu C et al (2022) Endothelial cell metabolic memory causes cardiovascular dysfunction in diabetes

The goal of this approach is to create a more balanced hormonal environment that encourages fat metabolism