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The relevance of this phenomenon in RBC aging in vivoto the extent this may result from/contribute to processes of age-related aberrant erythropoiesis and age-related comorbidities remains to be determined

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When ROS production exceeds the antioxidant capacity, ROS accumulate and can cause multiple cellular disruptions involved in multiple diseases [49,50,51,52,53,54,55,56,57,58]