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Description
The compound received FDA GRAS status for safety but was never approved as a drug because efficacy was insufficient for pharmaceutical registration

Unlike beta-1 receptors in cardiac tissue or beta-2 receptors in smooth muscle, beta-3 receptors are predominantly expressed in adipose tissue and bladder, with limited cardiovascular effects

The vast number of preclinical studies on NAD + modulation via precursors or modulators of NADase enzymes has established a tight functional relationship between NAD + metabolism and mitochondrial homeostasis

M., Yang, X., Kuboyama, T

[DOI] [PubMed] [Google Scholar] 185.Kopelman P, Bryson A, Hickling R, et al

Track your intake for at least the first 4 weeks to ensure you are consistently in deficit
