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Furthermore, NAC has been shown to influence redox-sensitive cell-signalling and transcription pathways, such as NF- B (which regulates proinflammatory genes), the p38, ERK1/2, SAPK/JNK, c-Jun, and c-Fos pathways, among others, in a wide variety of different systems [17, 21, 22]

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Histidine catabolism is a major determinant of methotrexate sensitivity