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Description
In the pathogenesis of PD, DA oxidation-associated oxidative stress (OS) drives -synuclein aggregation, the primary structural component of Lewy bodies and a pathological hallmark of PD [16]
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9,36 Consequently, this induces a pseudo-first-pass effect that interferes with drug absorption 37 and negatively affects the pharmacokinetic and pharmacodynamic profiles of the drugs
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pylori is removed (42)
Clark TM, Jones JM, Hall AG, et al
