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Indeed, the structure of the ECD may affect transport itself (mutations in the ECD increase the K M for carnitine 32 ), however, the structural basis for this is unclear

doi: 10.1016/j.schres.2019.03.019

Acta Neurobiol Exp (Wars) 77(4):269296 Gade M, Comfort N, Re DB (2021) Sex-specific neurotoxic effects of heavy metal pollutants: epidemiological, experimental evidence and candidate mechanisms