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Antioxidant supplementation abolishes lifespan extension, confirming that oxidative stress drives these effects

Validating these findings, we show that deletion of the mitochondrial pyruvate carrier, which is known to decrease TCA cycle activity and protect the liver from diet-induced injury, also diminished NADPH, elevated glutathione oxidation, and alleviated ER stress

Our results reveal that exogenously applied Cd reduced silage maize growth and impaired photosynthesis

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The neurometabolite levels of Glu, Gln, and GABA were assessed in the anterior cingulate cortex (ACC), thalamus, and right temporo-parietal junction (TPJ), with most quantifications passing quality checks