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Based on Phase 2 clinical trials, patients with T2DM who were inadequately managed with diet and exercise alone or were on a stable metformin regimen for at least 3 months before screening received once-weekly subcutaneous injections of tirzepatide at doses of 1 mg, 5 mg, 10 mg, or 15 mg for 26 weeks

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Nicotine-mediated autophagy of vascular smooth muscle cell accelerates atherosclerosis via Nachrs/Ros/Nf-Kappab signaling pathway