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We arbitrarily classified factors influencing the relationship between the prescribed oral dose of LT4 and the drugs clinical effectiveness into three broad categories: pharmaceutical factors (the dosing regimen, the time of day taken, the administration route, the pharmaceutical formulation), pathophysiological factors (aetiology, type of hypothyroidism, disease status, concomitant diseases or comorbidities, anthropometric variables, genetic variants, etc.), and behavioural (concomitant drug treatments, foods, compliance, the prescribing physicians characteristics, etc.) (Table 1)

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