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Additionally, nanoparticles possess advantages such as small particle size, high drug loading capacity, controlled drug release, efficient tumor targeting ability, and prolonged in vivo circulation time (142)

doi: 10.1007/s12250-018-0026-1 196 NiemanDC

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9 Immunosenescence is also regulated by signaling pathways such as the nuclear factor-kappa B (NF-B), mTOR, JAK-STAT, melatonin, and sirtuin pathways, whose dysregulation leads to aberrant immune responses and increased susceptibility to age-related diseases