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The most recent developments regarding therapies based on incretin hormones (glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP)) are likely to fundamentally change our therapy for type 2 diabetes mellitus (T2DM), obesity and conditions associated with diabetes and obesity, i

-A- D-Nle-Cys-Ile-NH-(CH 2 ) 5 -CONH 2s TM#TM D- Nle-Met-Ile-NH-(CH 2 ) 5 -CONH 2 D-Nle-Trp-Ile-NH-(CH 2 ) 5 - CONH 2 D-Nle-Trp-Ile-NH-(CH 2 ) 5 - CONH 2 FIG 24A and B Inhibition of HGF dimerization by D-Nle-X-IIe-NH-(CH 2 ) 5 -CONH 2 analogs