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Studies in the liver and skeletal muscle have shown that acetylation reduces PDH activity, and similar observations have since been made in cardiac tissue.34 , 35 This suggests that increased acetylation reduces metabolism and ATP production from glucose

Stimulates intense, localized angiogenesis via VEGF signaling pathways

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At the same time, the activation of HO-1-related pathways promotes the polarization of M2 macrophages to improve diabetic-inflammatory response, oxidative stress, and cell proliferation have been verified by various of studies [38,39,40]

Statistical analysis We compared the demographic characteristics of the insomnia subtypes and controls using Chi-square or Fishers exact test for categorical variables and t -tests or Wilcoxon signed-rank test for continuous variables

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