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While the activity of NHR-49 is regulated at multiple levels including cofactor interactions, heterodimerization with other nuclear receptors, and isoform-specific subcellular localization 23,42,45,46,47,48 , nuclear hormone receptors are classically defined as ligand-regulated transcription factors 49,50,51,52,53

Mitochondrial dynamics Role of mitochondria in cancer cells Tumor metabolism refers to the distinct metabolic characteristics exhibited by tumor cells during their processes of proliferation, growth, and invasion [74]

A balanced inflammatory process is crucial for tissue health, but excessive inflammatory reactions can cause additional cellular damage

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Arrojo EDR, Fonseca TL, Castillo M, Salathe M, Simovic G, Mohacsik P, et al