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Rg1 can effectively alleviate PD-associated motor and cognitive dysfunctions through various mechanisms, including the inhibition of neuroinflammation, reduction of oxidative stress, promotion of neuronal survival, and enhancement of synaptic plasticity

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Indeed, studies have demonstrated that transcriptomics in aged mice under heat stress reveals that heat stress simultaneously triggers intestinal barrier disruption (Xiao et al., 2015

and D.A.G have received funds from US National Institutes of Health (NIH) grants

8E) [179]

Varying definition of cases and controls, laboratory and analytical methods may account for the range of heterogeneity
