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With respect to fructose metabolism, experiments have demonstrated that the consumption of alcohol, and its metabolism in the liver, can lead to glucose diversion into fructose which is a direct contributor to hepatic lipogenesis and the development of hepatic steatosis

[132] Accumulation of evidence suggests that intracellular GSH (glutathione) levels in antigen-presenting cells such as macrophages, influence the TH1/TH2 cytokine response pattern

The future use of plant peptides in clinical and sports is increasing, as clinical studies validate their potential to influence inflammatory signaling and underline their safety and efficacy as components of dietary supplements

Among these, ferroptosis and mitochondrial damage have emerged as new areas of focus in recent years and are considered potential new therapeutic targets for DCM treatment

In another controlled study, the use of electric blankets to induce heat stress during the dry period led to an approximate 0.2 C increase in rectal temperature and a 6 kg/day decline in subsequent milk yield compared to unheated controls (Casarotto et al., 2025a)