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Research demonstrates that doxorubicin, a common chemotherapeutic agent, induces widespread cellular senescence in addition to its anti-cancer effects, contributing to severe off-target toxicity and long-term health complications in cancer survivors

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Hormonal changes can modulate these signaling pathways, altering fibroblast activity and collagen turnover rates, thereby impacting the structural integrity of the ACL

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A dose of 10 mg/kg significantly reduced spontaneous pain without signs of dependency or sedation