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The proteins in those foods could combine in a way that causes your immune system to recognize them as a threat, triggering an autoimmune flare-up
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Discordance between ex vivo potency and in vivo PK/PD has many potential causes, one of which, in the case of schistosomicidal agents, is the involvement of the host immune response

New insights in ferroptosis: Potential therapeutic targets for the treatment of ischemic stroke

FEMS Microbiol Rev (2015) 39(4):50921

When it occurs between a CHO molecule and a free amino group in a protein, it forms glycated proteins called Amadori products [44]

Similarly, the same mutation in rodents also causes increased ROS in Schwann cells and leads to death of primary Schwann cells in culture
